axon

There is soon the big neurology meeting: American Academy of Neurology (AAN) Annual Meeting 2010. Toronto, 10–17 Apr 2010. [aan10a]

Invited Speaker Session

• Zamboni P: Chronic Cerebrospinal Venous Insufficiency and Multiple Sclerosis: A Paradigm Shift in the Physiology of Cerebral Venous Return. 14 Apr 2010, 5.30pm - 5.50pm. Program (PDF) p67. [pres_zamboni10b]

Platform Session:

• Poloni GU, Zamboni P, Haacke EM, Bastianello S, Dwyer MG, Bergsland N, Schirda C, Wack D, Magnano C, Weinstock-Guttman B, Salvi F, Hojnacki D, Zivadinov R: Quantitative Venous Vasculature Assessment on Susceptibility-Weighted Imaging Reflects Presence of Severe Chronic Venous Insufficiency in the Brain Parenchyma of Multiple Sclerosis Patients. A Case-Control Study. 14 Apr, Integrated Neuroscience: Multiple Sclerosis Imaging (2:00 PM-3:30 PM). [pres_poloni10a]

5 Poster Sessions:

• Magnano C, Schirda C, Weinstock-Guttman B, Hojnacki D, Bergsland N, Kennedy C, Reuther J, Brooks C, Dwyer MG, Zivadinov R: Cine Cerebrospinal Fluid Imaging in Multiple Sclerosis. A Case-Control Study.14 Apr, Poster Session III: Multiple Sclerosis and Related Diseases: MRI/Technique (7:30 AM-12:00 PM). [pos_magnano10a]
• Zamboni P, Menegatti E, Weinstock-Guttman B, Dwyer MG, Schirda C, Malagoni AM, Hojnacki D, Kennedy C, Carl E, Bergsland N, Magnano C, Bartolomei I, Salvi F, Zivadinov R : Hypoperfusion of Brain Parenchyma Is Strongly Associated with the Severity of Chronic Cerebrospinal Venous Insufficiency in Patients with Multiple Sclerosis. 14 Apr, Poster Session III: Multiple Sclerosis and Related Diseases: MRI/Technique (7:30 AM-12:00 PM). [pos_zamboni10a]
• Dwyer MG, Zamboni P, Haacke EM, Menegatti E, Weinstock-Guttman B, Schirda C, Malagoni AM, Hojnacki D, Kennedy C, Carl E, Bergsland N, Hussein S, Heininen-Brown M, Bartolomei I, Salvi F, Zivadinov R: Chronic Cerebrospinal Venous Insufficiency and Iron Deposition on Susceptibility-Weighted Imaging in Patients with Multiple Sclerosis. 14 Apr, Poster Session III: Multiple Sclerosis and Related Diseases: MRI/Technique (7:30 AM-12:00 PM). [pos_dwyer10a]
• Schirda C, Zamboni P, Magnano C, Lindzen E, Wack D, Weinstock-Guttman B, Ramasamy D, Carl E, Hojnacki D, Kennedy C, Dwyer MG, Bergsland N, Cox JL, Salvi F, Zivadinov R: Objective Quantification of Cerebrospinal Fluid (CSF) Flow Rate in Cerebral Aqueduct in Patients with Multiple Sclerosis. 14 Apr, Poster Session: Integrated Neuroscience: Multiple Sclerosis Imaging (3:30 PM-4:30 PM). [pos_schirda10a]
• Zivadinov R, Marr K, Ramanathan M, Zamboni P, Benedict RRHB, Cutter G, Kennedy C, Elfadil M, Hojnacki D, Munschauer F, Reuther J, Brooks C, Hunt K, Andrews M, Weinstock-Guttman B: Combined Transcranial and Extracranial Venous Doppler Evaluation (CTEVD Study). Description of the Design and Interim Results of an Epidemiological Study of the Prevalence of Chronic Cerebrospinal Venous Insufficiency in MS and Related Diseases. 15 Apr, Poster Session VI: Multiple Sclerosis and Related Diseases: Clinical Trials (3:00 PM-7:30 PM). [pos_zivadinov10a]

Webcasts:

• Zamboni P, Zivadinov R, Common A, Miller A: Live web forum about CCSVI and MS. Hosted by MS Society and the American Academy of Neurology. 14 Apr 12:00 pm (noon) ET (or 18h CEST, Zurich). Register now online. See full article.[webcast_aan10]

Note: Saturday, Apr 10 7 pm ET on CTV The Liberation War. The fight between patients and the medical community over the MS treatment first revealed by W5 last November. CTV W5 Trailer (19s). (Or on Youtube). See full article.

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Haesun Kim, Assistant Professor, Rutgers University,Newark, N.J.Newark, NJ ? Uncover the neural communication links involved in myelination, the process of protecting a nerve?s axon, and it may become possible to reverse the breakdown of the nervous system?s electrical transmissions in such disorders as multiple sclerosis, spinal cord injuries, diabetes and cancers of the nervous system.

With $697,065 in grants from the New Jersey Commission on Spinal Cord Injury and the New Jersey Commission on Brain Injury Research, Haesun Kim of Teaneck, NJ, assistant professor of biological sciences at Rutgers University in Newark, is working on gaining a better understanding of those links.

Specifically, her work focuses on Schwann cells within the peripheral nervous system and their communication links with the axons they myelinate by enwrapping them in myelin. Axons are the long fibrous part of neurons that carry the nerve?s electrical signals. A fatty substance, myelin covers those axons both to protect them and to provide a conduit for the fast conduction of electrical signals within the nervous system. Once that myelin is lost,the electrical signal breaks down and eventually the neuron dies ? like a cell phone that loses its signal.

Determining how Schwann cells and axons communicate with one another could lead to an understanding of how to promote remyelination, the rebuilding of myelin, and restoration of that signal. One unique aspect of the communication link between Schwann cells and axons is that they are mutually dependent upon that connection for their existence.

?When Schwann cells are generated during development, axons send out signals to the Schwann cells and tell them, ?You are going to become myelin cells and you are going to myelinate me,?? explains Kim. ?The Schwann cells in turn guide the axons to where they need to go and direct the axons to grow.? continue reading »»»